Medical illustration for the Liver Cancer guide
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Liver Cancer

Primary cancer starting in liver cells. The most common is hepatocellular carcinoma.

Liver Cancer Overview

The liver is the largest internal organ. Most primary liver cancers develop in people with chronic liver disease, such as cirrhosis caused by Hepatitis B, C, or excessive alcohol use.
Medical illustration accompanying the Liver Cancer overview

Symptoms (Often Late)

  • Unintended weight loss and loss of appetite.
  • Pain in the upper right abdomen.
  • Jaundice (yellowing of skin and eyes).
  • Abdominal swelling (ascites) or visible veins on the belly.
  • White or chalky stools and dark urine.
  • General fatigue and weakness.

Therapeutic Challenges

Treatment is complex and relies heavily on the health of the remaining liver.

Surgical Resection or Transplant

Tumor removal (if liver works well) or liver replacement.

Ablation & Embolization Therapy

Techniques to destroy tumors directly without major surgery.

Sources and medical information

Prepared by Tutti Cancer Warriors

Sources checked: 28 July 2026

This page provides general educational information. It does not replace medical advice, diagnosis or treatment from a qualified healthcare professional. Signs and symptoms associated with primary liver cancer can also have other causes. Contact a healthcare professional about a hard lump or persistent discomfort in the upper-right abdomen, abdominal swelling, jaundice, pale stools and dark urine, unexplained weight loss, loss of appetite, unusual tiredness or other concerning symptoms. Chronic hepatitis B or C infection and cirrhosis increase risk; people living with chronic liver disease should discuss appropriate monitoring with their clinician. NCI SEER reports 21.9% five-year relative survival in the United States for liver and intrahepatic bile duct cancer, all stages combined, for 2016–2022. This population statistic groups different cancers and stages and cannot predict an individual outcome.

Official sources

Global Impact

843KNew liver and intrahepatic bile duct cancer cases globally in 2024 (IARC estimate)
21.9%Five-year relative survival in the US, liver and intrahepatic bile duct cancer, all stages combined, 2016–2022 (NCI SEER)

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